Insight into new opportunities in intra-surgical diagnostics of brain tumors

J Bogusiewicz, B Bojko - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Brain tumor removal is a crucial step in therapeutic regimens. In surgical interventions, the
ultimate goal is to completely resect the malignant lesion with a safe margin of healthy …

Dysfunction of the carnitine cycle in tumor progression

X Wang, C Yang, C Huang, W Wang - Heliyon, 2024 - cell.com
The carnitine cycle is responsible for the transport of cytoplasmic fatty acids to the
mitochondria for subsequent β-oxidation to maintain intracellular energy homeostasis …

Investigating the potential use of chemical biopsy devices to characterize brain tumor lipidomes

J Bogusiewicz, B Kupcewicz, PZ Goryńska… - International Journal of …, 2022 - mdpi.com
The development of a fast and accurate intraoperative method that enables the
differentiation and stratification of cancerous lesions is still a challenging problem in …

Solid-phase microextraction: a fit-for-purpose technique in biomedical analysis

B Bojko - Analytical and Bioanalytical Chemistry, 2022 - Springer
Solid-phase microextraction (SPME) possesses unique features that allow it to be used in
analyses that would not be possible with traditional sample-preparation methods. The …

Metabolomic phenotyping of gliomas: what can we get with simplified protocol for intact tissue analysis?

PZ Goryńska, K Chmara, B Kupcewicz, K Goryński… - Cancers, 2022 - mdpi.com
Simple Summary The diagnostic protocol for gliomas is based on histological examination
and the determination of genetic biomarkers. However, examining molecular biomarkers in …

Metabolic Contrasts: Fatty Acid Oxidation and Ketone Bodies in Healthy Brains vs. Glioblastoma Multiforme

C Tamas, F Tamas, A Kovecsi, A Cehan… - International Journal of …, 2024 - mdpi.com
The metabolism of glucose and lipids plays a crucial role in the normal homeostasis of the
body. Although glucose is the main energy substrate, in its absence, lipid metabolism …

High-throughput quantitation of amino acids and acylcarnitine in cerebrospinal fluid: identification of PCNSL biomarkers and potential metabolic messengers

J Ma, K Chen, Y Ding, X Li, Q Tang, B Jin… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Due to the poor prognosis and rising occurrence, there is a crucial need to
improve the diagnosis of Primary Central Nervous System Lymphoma (PCNSL), which is a …

[HTML][HTML] Carnitine analysis in food and biological samples: Chromatography and mass spectrometry insights

B Cheng, K Li, W Li, Y Liu, Y Zheng, Q Zhang… - Arabian Journal of …, 2024 - Elsevier
Carnitines, essential for human metabolism and fatty acid transport, are primarily obtained
from the diet. Inadequate synthesis or intake can lead to serious metabolic disorders, which …

The impact of sampling time point on the lipidome composition

J Bogusiewicz, B Kupcewicz, K Wnuk… - … of Pharmaceutical and …, 2024 - Elsevier
Lipidomic profiling has been reported as an effective approach for characterizing and
differentiating brain tumors. However, since lipids can undergo non-specific enzymatic and …

Coated blade spray-mass spectrometry as a new approach for the rapid characterization of brain tumors

J Bogusiewicz, M Gaca-Tabaszewska, D Olszówka… - Molecules, 2022 - mdpi.com
Brain tumors are neoplasms with one of the highest mortality rates. Therefore, the availability
of methods that allow for the quick and effective diagnosis of brain tumors and selection of …