Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder
T Gonatopoulos-Pournatzis, BJ Blencowe - Current opinion in genetics & …, 2020 - Elsevier
The discovery and characterization of a network of highly conserved neuronal microexons
has provided fundamental new insight into mechanisms underlying nervous system …
has provided fundamental new insight into mechanisms underlying nervous system …
Regulatory roles of the N-terminal intrinsically disordered region of modular Src
G Kato - International Journal of Molecular Sciences, 2022 - mdpi.com
Src, the prototype of Src family kinases (SFKs), is a modular protein consisting of SH4 (SH4)
and unique (UD) domains in an N-terminal intrinsically disordered region (IDR), and SH3 …
and unique (UD) domains in an N-terminal intrinsically disordered region (IDR), and SH3 …
Multisite tyrosine phosphorylation of the N‐terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein
CJR Dunning, HL Black, KL Andrews… - Journal of …, 2016 - Wiley Online Library
Mint/X11 is one of the four neuronal trafficking adaptors that interact with amyloid precursor
protein (APP) and are linked with its cleavage to generate β‐amyloid peptide, a key player in …
protein (APP) and are linked with its cleavage to generate β‐amyloid peptide, a key player in …
HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1
CDH Ratcliffe, N Siddiqui, PP Coelho… - Journal of Cell …, 2019 - rupress.org
Differential inclusion or skipping of microexons is an increasingly recognized class of
alternative splicing events. However, the functional significance of microexons and their …
alternative splicing events. However, the functional significance of microexons and their …
Discovery of anti-tumor small molecule lead compounds targeting the SH3 domain of c-Src protein through virtual screening and biological evaluation
H Hao, Y Bian, N Yang, X Ji, J Bao, K Zhu - Archives of Biochemistry and …, 2024 - Elsevier
Abstract c-Src, also known as cellular Src, is a non-receptor tyrosine kinase that plays a
crucial role in various cellular processes, including cell proliferation, adhesion, and …
crucial role in various cellular processes, including cell proliferation, adhesion, and …
Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM
S Keenan, SJ Wetherill, CI Ugbode, S Chawla… - Scientific Reports, 2017 - nature.com
In the mammalian brain the ubiquitous tyrosine kinase, C-Src, undergoes splicing to insert
short sequences in the SH3 domain to yield N1-and N2-Src. We and others have previously …
short sequences in the SH3 domain to yield N1-and N2-Src. We and others have previously …
N1-Src kinase is required for primary neurogenesis in Xenopus tropicalis
The presence of the neuronal-specific N1-Src splice variant of the C-Src tyrosine kinase is
conserved through vertebrate evolution, suggesting an important role in complex nervous …
conserved through vertebrate evolution, suggesting an important role in complex nervous …
Revealing the complexity of isoform diversity in brain development
PDBC de Toledo - 2023 - tud.qucosa.de
Abstract (EN) During evolution, the mammalian cerebral cortex has undergone a
considerable increase in size and complexity. The emergence of the cortical structure …
considerable increase in size and complexity. The emergence of the cortical structure …
Analysis of Src dynamics in cellular structures
M Pelantová - 2021 - dspace.cuni.cz
Src kinase is a key element in many signaling pathways affecting cellular processes such as
differentiation, proliferation, motility, or migration. Deregulation of its activity is associated …
differentiation, proliferation, motility, or migration. Deregulation of its activity is associated …
[PDF][PDF] Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
CC Sneddon - discovery.dundee.ac.uk
Utilising the LB paradigm to generate FC not only results in immediate behavioural change
in the dam and pups but also a developmental effect. Upon removal from the FC cage pups …
in the dam and pups but also a developmental effect. Upon removal from the FC cage pups …