Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Plant-based psychedelics, such as psilocybin, have an ancient history of medicinal use.
After the first English language report on LSD in 1950, psychedelics enjoyed a short-lived …

Exercise displays promise as an efficacious treatment for people with depression. However,
no systematic review has evaluated the neurobiological effects of exercise among people …

Background: Stress is a common reaction to an environmental adversity, but a dysregulation
of the stress response can lead to psychiatric illnesses such as major depressive disorder …

Abstract Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …

5-Hydroxytryptamine 2A receptors (5-HT2A-Rs) are G-protein coupled receptors. In
agreement with their location in the brain, they have been implicated not only in various …

Based on the discovery of the robust antidepressant effects of ketamine in patients with
depression, including those with treatment-resistant depression, agents acting on the …

Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to
neuroplasticity regulation and are implicated in numerous neuronal disorders. Here, we …

The available interventions for people who are at risk of suicide have limited efficacy.
Recently, research on new mental health treatments has started to consider psychedelic …