In accordance with the comorbidity-inflammation paradigm, comorbidities and especially
metabolic comorbidities are presumed to drive development and severity of heart failure with …

Unresolved inflammation is a key mediator of advanced heart failure. Especially, damage,
pathogen, and lifestyle-associated molecular patterns are the major factors in initiating …

Objectives The goal of this study was to evaluate the effect of empagliflozin, in addition to
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …

Background Patients with pre-existing heart failure (HF) are likely at higher risk for adverse
outcomes in coronavirus disease-2019 (COVID-19), but data on this population are sparse …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Inflammation has been recognized as a major pathophysiological contributor to the entire
spectrum of human heart failure (HF), including HF with reduced ejection fraction, HF with …

Congestion explains many of the signs and symptoms of acute heart failure (AHF) and
disease progression. However, accurate quantification of congestion is challenging in daily …

Aims CONCERT‐HF is an NHLBI‐sponsored, double‐blind, placebo‐controlled, Phase II
trial designed to determine whether treatment with autologous bone marrow‐derived …

Abstract The coronavirus-2019 (COVID-19) infection pandemic has affected the care of
patients with heart failure (HF) who have contracted COVID-19 as well as those without …

Cardiac macrophages represent a heterogeneous cell population with distinct origins,
dynamics, and functions. Recent studies have revealed that CC Chemokine Receptor 2 …