Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

Abstract A short, 14-amino-acid segment called SP1, located in the Gag structural protein,
has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the …

Like other enveloped viruses, HIV-1 uses cellular machinery to bud from infected cells. We
now show that Tsg101 protein, which functions in vacuolar protein sorting (Vps), is required …

During the early stages of infection, the HIV-1 capsid protects viral components from
cytosolic sensors and nucleases such as cGAS and TREX, respectively, while allowing …

Human immunodeficiency virus type 1 (HIV-1) assembly proceeds in two stages. First, the
55 kilodalton viral Gag polyprotein assembles into a hexameric protein lattice at the plasma …

The genome of the human immunodeficiency virus (HIV) is packaged within an unusual
conical core particle located at the center of the infectious virion. The core is composed of a …

The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for
the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life …

The mature capsids of HIV and other retroviruses organize and package the viral genome
and its associated enzymes for delivery into host cells. The HIV capsid is a fullerene cone: a …