Abstract CMG (Cdc45‐MCM‐GINS) helicase assembly at the replication origin is the
culmination of eukaryotic DNA replication initiation. This process can be reconstructed in …

Characterizing the molecular deficiencies underlying human aging has been a formidable
challenge as it is clear that a complex myriad of factors including genetic mutations …

Replication stress refers to slowing or stalling of replication fork progression during DNA
synthesis that disrupts faithful copying of the genome. While long considered a nexus for …

Cancer initiation and progression are typically associated with the accumulation of driver
mutations and genomic instability. However, recent studies demonstrated that cancer can …

Non-homologous end joining (NHEJ) is the major pathway that mediates the repair of DNA
double-strand breaks (DSBs) generated by ionizing radiation (IR). Previously, the DNA …

For over a decade, it has been known that yeast Sld2, Dpb11, GINS and Polε form the pre-
loading complex (pre-LC), which is recruited to a CDC45-bound MCM2–7 complex by the …

Simple Summary The molecular and cellular radiosensitivity associated with the Rothmund–
Thomson syndrome has been investigated in the framework of a mechanistic model based …

Inborn errors of immunity are a heterogeneous group of monogenic immunologic disorders
caused by mutations in genes with critical roles in the development, maintenance, or …

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized
by a range of clinical symptoms, including poikiloderma, juvenile cataracts, short stature …

Rothmund-Thomson syndrome (RTS) is a rare autosomal-recessive disorder with clinical
features consisting of rash, poikiloderma, sparse hair, short stature, juvenile cataracts …