Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity
X Pang, C Tang, R Guo, X Chen - Pharmacology & Therapeutics, 2022 - Elsevier
Oxidative metabolism is one of the major biotransformation reactions that regulates the
exposure of xenobiotics and their metabolites in the circulatory system and local tissues and …
exposure of xenobiotics and their metabolites in the circulatory system and local tissues and …
Copper ionophores as novel antiobesity therapeutics
PM Meggyesy, S Masaldan, SAS Clatworthy, I Volitakis… - Molecules, 2020 - mdpi.com
The therapeutic utility of the copper ionophore disulfiram was investigated in a diet-induced
obesity mouse model (C57BL/6J background), both through administration in feed (0.05 to …
obesity mouse model (C57BL/6J background), both through administration in feed (0.05 to …
Synergistic toxicity of epigallocatechin-3-gallate and diethyldithiocarbamate, a lethal encounter involving redox-active copper
K Zhang, R Dong, K Sun, X Wang, J Wang… - Free Radical Biology …, 2017 - Elsevier
Dithiocarbamates (DTC) are widely used in agricultural, industrial and therapeutic domains.
There are ample opportunities for human exposure to DTC. Green tea extracts, with …
There are ample opportunities for human exposure to DTC. Green tea extracts, with …
A phase I study of DMS612, a novel bifunctional alkylating agent
LJ Appleman, S Balasubramaniam, RA Parise… - Clinical Cancer …, 2015 - AACR
Purpose: DMS612 is a dimethane sulfonate analog with bifunctional alkylating activity and
preferential cytotoxicity to human renal cell carcinoma (RCC) in the NCI-60 cell panel. This …
preferential cytotoxicity to human renal cell carcinoma (RCC) in the NCI-60 cell panel. This …
Characterization of the metabolism of benzaldehyde dimethane sulfonate (NSC 281612, DMS612)
RA Parise, JL Eiseman, DM Clausen… - Cancer chemotherapy …, 2015 - Springer
Introduction Benzaldehyde dimethane sulfonate (BEN, DMS612, NSC281612) is a
bifunctional alkylating agent currently in clinical trials. We previously characterized the …
bifunctional alkylating agent currently in clinical trials. We previously characterized the …
Insights into the metabolic characteristics of aminopropanediol analogues of SYLs as S1P1 modulators: from structure to metabolism
M Zhao, J Mi, B Wang, Q Xiao, Y Tian, J Hu… - European Journal of …, 2021 - Elsevier
SYL927 and SYL930, two aminopropanediol analogues, are novel Sphingosine-1-
phosphate receptor 1 (S1P 1) modulators with higher selectivity and pharmacological …
phosphate receptor 1 (S1P 1) modulators with higher selectivity and pharmacological …
THE PRECLINICAL AND CLINICAL PHARMACOLOGY OF BENZALDEHYDE DIMETHANE SULFONATE (BEN) FOR THE TREATMENT OF RENAL CELL …
RA Parise - 2014 - d-scholarship.pitt.edu
Over 65,000 people acquired renal cell carcinoma (RCC) and over 13,500 people died from
the disease in the United States in 2012. The median survival for persons with metastatic …
the disease in the United States in 2012. The median survival for persons with metastatic …