Meiotic recombination is a fundamental feature of sexually reproducing species. It is often
required for proper chromosome segregation and plays important role in adaptation and the …

A remarkable suite of forms of genomic conflict has recently been implicated in speciation.
We propose that these diverse roles of genomic conflict in speciation processes can be …

Human genetic variation is distributed nonrandomly across the genome, though the
principles governing its distribution are only partially known. DNA replication creates …

Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of
chromosomes obtains at least one crossover, even though the majority of recombination …

Background In sexually reproducing organisms, meiotic crossovers ensure the proper
segregation of chromosomes and contribute to genetic diversity by shuffling allelic …

Studies of highly diverged species have revealed two mechanisms by which meiotic
recombination is directed to the genome—through PRDM9 binding or by targeting promoter …

Meiotic recombination is required for the segregation of homologous chromosomes and is
essential for fertility. In most mammals, the DNA double-strand breaks (DSBs) that initiate …

Regulation of gene expression is achieved by sequence-specific transcriptional regulators,
which convey the information that is contained in the sequence of DNA into RNA …

Intratumour heterogeneity and phenotypic plasticity, sustained by a range of somatic
aberrations, as well as epigenetic and metabolic adaptations, are the principal mechanisms …

PRDM9 binding localizes almost all meiotic recombination sites in humans and mice.
However, most PRDM9-bound loci do not become recombination hotspots. To explore …