As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial
roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a …

Inflammation and fibrosis are intertwined mechanisms fundamentally involved in heart
failure. Detailed deciphering gene expression perturbations and cell–cell interactions of …

Abstract FUN14 domain-containing protein 1 (Fundc1)-dependent mitophagy, mainly
activated by ischemic/hypoxic preconditioning, benefits acute myocardial reperfusion injury …

Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …

Myocardial fibrosis represents the primary pathological change associated with diabetic
cardiomyopathy and heart failure, and it leads to decreased myocardial compliance with …

Background. Inflammation and oxidative stress are involved in the initiation and progress of
heart failure (HF). However, the role of the IL6/STAT3 pathway in the pressure overload …

Heart failure (HF), the main cause of death in patients with many cardiovascular diseases,
has been reported to be closely related to the complicated pathogenesis of autophagy …

Epigenetic mechanisms involve the placing (writing) or removal (erasing) of histone
modifications that allow heterochromatin to transition to the open, activated euchromatin …

Cardiac fibrosis is a common precursor of ventricular dysfunction and heart failure. We
investigated the role of oxidative stress in myocardial fibrosis and the protective effect of …