The average lifespan of circulating erythrocytes usually exceeds hundred days. Prior to that,
however, erythrocytes may be exposed to oxidative stress in the circulation which could …

Sickle cell disease (SCD) is an inherited blood disorder most common among African
American and Hispanic American persons. The disease can cause substantial, long-term …

Sickle cell disease (SCD) is a genetic disease influenced by ethnicity and regional
differences in its clinical course. Recent advances in the management of SCD with newer …

Abstract Problem/Condition: Sickle cell disease (SCD), an inherited blood disorder affecting
an estimated 100,000 persons in the United States, is associated with multiple complications …

Background and purpose The majority of the reviews and studies on chronic pain in
pregnancy have primarily focused on the pharmacological and non-pharmacological …

Background Providers and patients have called for improved understanding of the health
care requirements of adults with sickle cell disease (SCD) and have identified the need for a …

Red blood cell transfusions have become standard of care for the prevention of life‐
threatening anemia in patients with β‐thalassemia and sickle cell disease (SCD). However …

Beyond initial discovery of a pathogenic variant, establishing that a variant is recurrently
associated with disease is important for understanding clinical impact and disease etiology …

Sickle cell disease (SCD) is a hereditary chronic hemolytic anemia with numerous clinical
consequences. Intravascular sickling of red blood cells leads to multiorgan dysfunction …

Objective. Voxelotor is a first‐in‐class sickle hemoglobin–polymerization inhibitor that was
approved in 2019 by the US Food and Drug Administration for treatment of patients with …