Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

The relatively common occurrence of sequences within proteins that match the consensus
substrate specificity of caspases in intracellular proteins suggests a multitude of substrates …

Structure-based design has emerged as a new tool in medicinal chemistry. A prerequisite for
this new approach is an understanding of the principles of molecular recognition in protein …

Three-dimensional quantitative structure− activity relationship (3D QSAR) methods were
applied using a training set of 72 inhibitors of the benzamidine type with respect to their …

Being in the Neurath laboratory gave me an excellent chance to interact with his other
graduate students and postdoctoral fellows. Individuals such as Leon Cunningham gave me …

Potent anticoagulants have been derived by targeting the tissue factor–factor VIIa complex
with naive peptide libraries displayed on M13 phage. The peptides specifically block the …

Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …

Cell signaling by coagulation factor Xa (Xa) contributes to pro-inflammatory responses in
vivo. This study characterizes the signaling mechanism of Xa in a HeLa cell line that …

Any vascular injury triggers the burst-like release of the trypsin-like serine proteinase α-
thrombin. Thrombin, the main executioner of the coagulation cascade, exhibits procoagulant …