Recent research has shown the essential role of reduced blood flow and free radical
formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and …

Two major classes of drugs currently in clinical use can cause permanent hearing loss.
Aminoglycoside antibiotics have a major role in the treatment of life-threatening infections …

Purpose: The aim of this study is to evaluate the neuroprotective effect of antioxidant
supplementation with vitamin E in patients treated with cisplatin chemotherapy. Methods …

Cisplatin, a commonly used chemotherapeutic agent, has a major limitation due to its
ototoxicity. Previous studies have shown that cisplatin induces apoptosis in auditory sensory …

This paper will focus on understanding the role and action of reactive oxygen species (ROS)
and reactive nitrogen species (RNS) in the molecular and biochemical pathways …

Mitochondrial dysfunction is associated with the etiologies of sensorineural hearing loss,
such as age-related hearing loss, noise-and ototoxic drug-induced hearing loss, as well as …

Abstract Objectives/Hypothesis Cisplatin ototoxicity is a major dose‐limiting factor in the
treatment of several neoplasms. Vitamin E, a slow‐acting free radical scavenger, has been …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in
sensory cell and neural death in the peripheral nervous system, including damage induced …

The main purpose of the present study is to develop a novel nano-emulsion (NE) formulation
of α-tocopherol (α-TC) with enhanced oral bioavailability and pharmacological effects. Three …

Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This
review addresses the signaling pathways that are involved in the programmed and necrotic …