A review: Synthetic approaches and biological applications of triazole derivatives
The triazole scaffold is a key element in heterocyclic chemistry, giving a fundamental
building block in organic, medicinal chemistry, and material science. Triazole composed of a …
building block in organic, medicinal chemistry, and material science. Triazole composed of a …
Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress
Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
Homocysteine fluorescent probes: Sensing mechanisms and biological applications
Homocysteine, cysteine, and glutathione are small molecules containing thiols that have
important functions in several physiological and pathological processes in living beings …
important functions in several physiological and pathological processes in living beings …
Recent developments on microwave-assisted organic synthesis of nitrogen-and oxygen-containing preferred heterocyclic scaffolds
In recent decades, the utilization of microwave energy has experienced an extraordinary
surge, leading to the introduction of innovative and revolutionary applications across various …
surge, leading to the introduction of innovative and revolutionary applications across various …
A comprehensive overview of coumarinyl-triazole hybrids as anticancer agents
There are over 100 commercially available drugs for the handling of cancer, but only a
handful of them have high specificity, leading to a variety of side effects. The past few …
handful of them have high specificity, leading to a variety of side effects. The past few …
Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin–Chalcone, and Coumarin–Triazole Molecular Hybrids
Molecular hybridization represents a new approach in drug discovery in which specific
chromophores are strategically combined to create novel drugs with enhanced therapeutic …
chromophores are strategically combined to create novel drugs with enhanced therapeutic …
Synthesis of new sulfamate linked 4-hydroxycoumarin conjugates as potent anti-α-amylase agents: In vitro approach coupled with molecular docking, DFT calculation …
A Assel, A Hajlaoui, H Lazrag, M Manachou… - Journal of Molecular …, 2023 - Elsevier
This work describes the design and synthesis of new coumarin-sulfamate derivatives by the
action of a series of aliphatic alcohols on (4-hydroxycoumarine-3-carbonyl) sulfamoyl …
action of a series of aliphatic alcohols on (4-hydroxycoumarine-3-carbonyl) sulfamoyl …
A medicinal chemist's perspective towards structure activity relationship of heterocycle based anticancer agents
Aim: This paper aims to describe the structure activity relationship of heterocyclic derivatives
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …
Coumarin-1, 2, 3-triazole hybrids as leading-edge anticancer agents
KN Mishra, HC Upadhyay - Frontiers in Drug Discovery, 2022 - frontiersin.org
Cancer is one of the most feared and dreaded diseases across the world. In clinical practice,
a variety of anticancer agents of natural, semi-synthetic and synthetic origin exist, but they …
a variety of anticancer agents of natural, semi-synthetic and synthetic origin exist, but they …
[HTML][HTML] Synthesis, characterization, anticancer activity, molecular docking and DFT calculation of 3-acetylcoumarin thiosemicarbazones and Schiff's bases
The new thiosemicarbazones (3a-d) of 3-acetylumbelliferone and Schiff's bases (4a-b) of 3-
acetylcoumarin were synthesized, characterized by elemental analysis, UV–Vis, FT-IR …
acetylcoumarin were synthesized, characterized by elemental analysis, UV–Vis, FT-IR …