Crocin molecular signaling pathways at a glance: A comprehensive review

M Boozari, H Hosseinzadeh - Phytotherapy Research, 2022 - Wiley Online Library
Crocin is a hydrophilic carotenoid that is synthesized in the flowers of the Crocus genus.
Numerous in vitro and in vivo research projects have been published about the biological …

Redox modulation by plant polyphenols targeting vitagenes for chemoprevention and therapy: Relevance to novel anti-cancer interventions and mini-brain organoid …

M Scuto, ML Ontario, AT Salinaro, I Caligiuri… - Free Radical Biology …, 2022 - Elsevier
The scientific community, recently, has focused notable attention on the chemopreventive
and therapeutic effects of dietary polyphenols for human health. Emerging evidence …

Crocin inhibits the migration, invasion, and epithelial‐mesenchymal transition of gastric cancer cells via miR‐320/KLF5/HIF‐1α signaling

Y Zhou, Q Xu, J Shang, L Lu… - Journal of cellular …, 2019 - Wiley Online Library
The biological activities of crocin, one of the main bioactive compounds of saffron, include
anti‐inflammatory, antioxidant, antidepressant, and anticancer effects. Crocin has been …

[HTML][HTML] Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

D Liu, L Chen, H Zhao, ND Vaziri, SC Ma… - Biomedicine & …, 2019 - Elsevier
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …

Immunometabolism modulation, a new trick of edible and medicinal plants in cancer treatment

W Tan, T Pan, S Wang, P Li, Y Men, R Tan, Z Zhong… - Food chemistry, 2022 - Elsevier
The edible and medicinal plants (EMPs) are becoming an abundant source for cancer
prevention and treatment since the natural and healthy trend for modern human beings …

Carotenoids in cancer metastasis—Status quo and outlook

L Koklesova, A Liskova, M Samec, K Zhai, M Abotaleb… - Biomolecules, 2020 - mdpi.com
Metastasis represents a major obstacle in cancer treatment and the leading cause of cancer-
related deaths. Therefore, the identification of compounds targeting the multi-step and …

Inhibitory effect of crocin on metastasis of triple-negative breast cancer by interfering with Wnt/β-catenin pathway in murine model

L Arzi, A Farahi, N Jafarzadeh, G Riazi… - DNA and Cell …, 2018 - liebertpub.com
Triple-negative breast cancer (TNBC) is the most metastatic subtype of breast cancer and
cannot be controlled with any standard-of-care therapy. However, various studies have …

A comparative study on inhibition of breast cancer cells and tumors in mice by carotenoid extract and nanoemulsion prepared from sweet potato (Ipomoea batatas L.) …

HY Hsu, BH Chen - Pharmaceutics, 2022 - mdpi.com
The objectives of this study were to determine carotenoid composition in sweet potato
(TNG66) peel and prepare carotenoid nanoemulsion to study its inhibition effect on breast …

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β‐Catenin Signaling Pathway and Glial Activation

JF Wang, HJ Xu, ZL He, Q Yin, W Cheng - Neural plasticity, 2020 - Wiley Online Library
At present, most of the drugs have little effect on the pathological process of rheumatoid
arthritis (RA). Analgesia is an important measure in the treatment of RA and is also one of …

Natural products against renin-angiotensin system for antifibrosis therapy

T Yang, YY Chen, JR Liu, H Zhao, ND Vaziri… - European journal of …, 2019 - Elsevier
Fibrosis is a final pathological feature of many chronic diseases, but few interventions are
available that specifically target the pathogenesis of fibrosis. The highlights of common …