[HTML][HTML] Genetic background of epilepsy and antiepileptic treatments

K Borowicz-Reutt, J Czernia, M Krawczyk - International Journal of …, 2023 - mdpi.com
Advanced identification of the gene mutations causing epilepsy syndromes is expected to
translate into faster diagnosis and more effective treatment of these conditions. Over the last …

Neonatal seizures

NS Abend, CJ Wusthoff, FE Jensen, TE Inder… - Volpe's Neurology of the …, 2025 - Elsevier
Seizures are the most distinctive and frequent manifestations of neurological disease in the
neonatal period. Compared with seizures in older patients, neonatal seizures have different …

[HTML][HTML] Efficacy and safety of ketamine for neonatal refractory status epilepticus: case report and systematic review

JN Pin, L Leonardi, M Nosadini, ME Cavicchiolo… - Frontiers in …, 2023 - frontiersin.org
Background Evidence-based data on treatment of neonatal status epilepticus (SE) are
scarce. We aimed to collect data on the efficacy and safety of ketamine for the treatment of …

Treating Seizures and Improving Newborn Outcomes for Infants with Hypoxic-Ischemic Encephalopathy

T Anwar, RL Triplett, A Ahmed… - Clinics in …, 2024 - perinatology.theclinics.com
Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal seizures. 1
Seizures in neonates with HIE peak in the first days after birth and are often subclinical. 1 …

Neonatal Cardiac Arrest Following Lacosamide Treatment: A Case Report

MA Huberman, C Mallar, PM Kalika - Pediatric neurology, 2023 - Elsevier
Background Lacosamide is an antiepileptic drug with US Food and Drug Administration
approval for the treatment of partial-onset seizures in patients older than one month …

[HTML][HTML] Precision treatments in epilepsy

S Demarest, A Brooks-Kayal - Neurotherapeutics, 2021 - Springer
The genomic revolution has resulted in the discovery of hundreds of genetic etiologies for a
variety of epilepsies and allowed science to probe the mechanisms of acquired epilepsies …

[HTML][HTML] Questions and Controversies in Neonatal Seizures

AM Cappellari, S Palumbo, S Margiotta - Children, 2023 - mdpi.com
Neonatal seizures are relatively common, but their diagnosis and management remain
challenging. We reviewed the scientific literature on neonatal seizures from July 1973 to …

Therapeutic Hypothermia for Neonatal Hypoxic–Ischemic Encephalopathy: Reducing Variability in Practice through a Collaborative Telemedicine Initiative

DMK Leandro, GFT Variane, A Dahlen… - American Journal of …, 2024 - thieme-connect.com
Objective This study aimed to assess the viability of implementing a tele-educational training
program in neurocritical care for newborns diagnosed with hypoxic–ischemic …

[HTML][HTML] Ionic plasticity: common mechanistic underpinnings of pathology in spinal cord injury and the brain

KE Hudson, JW Grau - Cells, 2022 - mdpi.com
The neurotransmitter GABA is normally characterized as having an inhibitory effect on
neural activity in the adult central nervous system (CNS), which quells over-excitation and …

Antibiotic Analgesic-Sedative and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review

A Kontou, E Agakidou, I Chatziioannidis, W Chotas… - 2024 - preprints.org
Several studies have shown that antibiotics, analgesic–sedative, and antiseizure
medications are among the most commonly used medications in preterm and sick neonates …