BACKGROUND Transmission electron microscopy offers structural and compositional
information with atomic resolution, but its use is restricted to thin, solid samples. Liquid …

In this paper we report, clarify and broaden various recent efforts to complement the
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …

Liquid cell transmission electron microscopy (LCTEM) can provide direct observations of
solution-phase nanoscale materials, and holds great promise as a tool for monitoring …

Liquid-phase transmission electron microscopy (TEM) can probe and visualize dynamic
events with structural or functional details at the nanoscale in a liquid medium. Earlier efforts …

In this paper we present in situ transmission electron microscopy of synthetic polymeric
nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The …

A central focus of biological research is understanding the structure/function relationship of
macromolecular protein complexes. Yet conventional transmission electron microscopy …

We describe the dynamics of 3–10 nm gold nanoparticles encapsulated by∼ 30 nm liquid
nanodroplets on a flat solid substrate and find that the diffusive motion of these …

In the last two decades, a wealth of structural and functional knowledge has been obtained
for the three major cytoskeletal motor proteins, myosin, kinesin and dynein, which we review …

Biological processes occur on a wide range of spatial and temporal scales: from
femtoseconds to hours and from angstroms to meters. Many new biological insights can be …

Although evidence has been presented that, at low ionic strength, myosin heads in relaxed
skeletal muscle fibers form linkages with actin filaments, the effect of low ionic strength on …