[HTML][HTML] Global identification of SWI/SNF targets reveals compensation by EP400
BJE Martin, EF Ablondi, C Goglia, CA Mimoso… - Cell, 2023 - cell.com
Mammalian SWI/SNF chromatin remodeling complexes move and evict nucleosomes at
gene promoters and enhancers to modulate DNA access. Although SWI/SNF subunits are …
gene promoters and enhancers to modulate DNA access. Although SWI/SNF subunits are …
[HTML][HTML] SWI/SNF-dependent genes are defined by their chromatin landscape
L Basurto-Cayuela, JA Guerrero-Martínez… - Cell Reports, 2024 - cell.com
SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …
Enhancer switching in cell lineage priming is linked to eRNA, Brg1's AT-hook, and SWI/SNF recruitment
RNA transcribed from enhancers, ie, eRNA, has been suggested to directly activate
transcription by recruiting transcription factors and co-activators. Although there have been …
transcription by recruiting transcription factors and co-activators. Although there have been …
MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
C Göbel, S Godbole, M Schoof, D Holdhof… - Acta Neuropathologica …, 2023 - Springer
Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors.
Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes …
Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes …
[HTML][HTML] Activity-assembled nBAF complex mediates rapid immediate early gene transcription by regulating RNA polymerase II productive elongation
KG Cornejo, A Venegas, MH Sono, M Door… - Cell reports, 2024 - cell.com
Signal-dependent RNA polymerase II (RNA Pol II) productive elongation is an integral
component of gene transcription, including that of immediate early genes (IEGs) induced by …
component of gene transcription, including that of immediate early genes (IEGs) induced by …
[HTML][HTML] The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds
J Ramachandran, W Chen, RK Lex, KE Windsor… - Developmental …, 2023 - Elsevier
Transcriptional responses to the Hedgehog (HH) signaling pathway are primarily modulated
by GLI repression in the mouse limb. Previous studies suggested a role for the BAF …
by GLI repression in the mouse limb. Previous studies suggested a role for the BAF …