Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant
and pan-drug resistant pathogens which are associated with considerable mortality …

Gram-positive bacteria are responsible for a broad range of infectious diseases, and the
emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA …

In the current practices of antiinfective therapy, ciprofloxacin is a very popular
fluoroquinolone having a broad spectrum of activity and diverse therapeutic prospects. The …

Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …

4-Phenyl-5-pyridin-4-yl-4H-1, 2, 4-triazole-3-thiol (3) was obtained in basic media via the
formation of 2-isonicotinoyl-N-phenylhydrazinecarbothioamide (2), and converted to some …

5-Pyridin-4-yl-1, 3, 4-oxadiazole-2-thiol (2) was obtained from the reaction of isonicotinic
acid hydrazide with carbon disulfide in basic media and converted into 4-amino-5-pyridin-4 …

The piperazine scaffold is a privileged structure frequently found in biologically active
compounds. Piperazine nucleus is found in many marketed drugs in the realm of …

Among all heterocycles, the triazine scaffold occupies a prominent position, possessing a
broad range of biological activities. Triazine is found in many potent biologically active …