Primary liver cancer is the third leading cause of cancer-related death worldwide. Most
patients are diagnosed at late stages with poor prognosis; thus, identification of modifiable …

Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors
produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to …

Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a
multifaceted molecular pathogenesis. Current evidence indicates that during …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

MicroRNAs are negative regulators of protein coding genes. The liver-specific microRNA-
122 (miR-122) is frequently suppressed in primary hepatocellular carcinomas (HCCs). In …

Hepatocellular carcinoma (HCC) is associated with a poor prognosis due to late diagnoses
and a lack of effective treatment options. Epidermal growth factor receptor (EGFR)–targeted …

Hepatocellular carcinoma (HCC) is a hypervascular cancer characterized by rapid
progression as well as resistance to conventional chemotherapy. It has been shown that …

A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT
and PDGFR α. These so-called wild-type (WT) GISTs tend to be less responsive to imatinib …

Survivin is a dual regulator of cell proliferation and cell viability overexpressed in most
human tumors. Although strategies to lower survivin levels have been pursued for rational …

Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …