Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Endothelial dysfunction and immunothrombosis in sepsis

E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

New fundamentals in hemostasis

HH Versteeg, JWM Heemskerk, M Levi… - Physiological …, 2013 - journals.physiology.org
Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Shock induced endotheliopathy (SHINE) in acute critical illness-a unifying pathophysiologic mechanism

PI Johansson, J Stensballe, SR Ostrowski - Critical Care, 2017 - Springer
One quarter of patients suffering from acute critical illness such as severe trauma, sepsis,
myocardial infarction (MI) or post cardiac arrest syndrome (PCAS) develop severe …

Inflammation and coagulation

M Levi - … : From Molecular and Cellular Mechanisms to the Clinic, 2017 - Wiley Online Library
In the majority of patients with systemic inflammatory conditions, some degree of activation
of coagulation is present. Increasing evidence points to an extensive cross‐talk between …

Points of control in inflammation

C Nathan - Nature, 2002 - nature.com
Inflammation is a complex set of interactions among soluble factors and cells that can arise
in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury …

The coagulopathy of acute sepsis

J Simmons, JF Pittet - Current Opinion in Anesthesiology, 2015 - journals.lww.com
The coagulopathy of acute sepsis : Current Opinion in Anesthesiology The coagulopathy of
acute sepsis : Current Opinion in Anesthesiology Log in or Register Subscribe to journalSubscribe …

[HTML][HTML] Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines

H Wada, J Thachil, M Di Nisio, P Mathew… - Journal of thrombosis …, 2013 - Elsevier
Disseminated intravascular coagulation (DIC) is a syndrome characterized by the systemic
activation of blood coagulation, which generates intravascular fibrin, leading to thrombosis …

The immunopathogenesis of sepsis

J Cohen - Nature, 2002 - nature.com
Sepsis is a condition that results from a harmful or damaging host response to infection.
Many of the components of the innate immune response that are normally concerned with …