Small-molecule antibiotic drug development: need and challenges
M Bergkessel, B Forte, IH Gilbert - ACS Infectious Diseases, 2023 - ACS Publications
The need for new antibiotics is urgent. Antimicrobial resistance is rising, although currently,
many more people die from drug-sensitive bacterial infections. The continued evolution of …
many more people die from drug-sensitive bacterial infections. The continued evolution of …
All-cause mortality rates in adults with carbapenem-resistant Gram-negative bacterial infections: a comprehensive review of pathogen-focused, prospective …
Introduction Pathogen-focused, randomized, controlled trials (PF-RCT) are important in the
fight against carbapenem-resistant (CR) Gram-negative infections. Some recently approved …
fight against carbapenem-resistant (CR) Gram-negative infections. Some recently approved …
The case against antibiotics and for anti-virulence therapeutics
JA Hotinger, ST Morris, AE May - Microorganisms, 2021 - mdpi.com
Although antibiotics have been indispensable in the advancement of modern medicine,
there are downsides to their use. Growing resistance to broad-spectrum antibiotics is …
there are downsides to their use. Growing resistance to broad-spectrum antibiotics is …
Systematic Review of Antimicrobial Combination Options for Pandrug-Resistant Acinetobacter baumannii
Antimicrobial combinations are at the moment the only potential treatment option for
pandrug-resistant A. baumannii. A systematic review was conducted in PubMed and Scopus …
pandrug-resistant A. baumannii. A systematic review was conducted in PubMed and Scopus …
How to tailor recommendations on the treatment of multi-drug resistant Gram-negative infections at country level integrating antibiotic stewardship principles within the …
E Carrara, PA Grossi, A Gori… - The Lancet Infectious …, 2024 - thelancet.com
Promoting the optimal use of antibiotics through evidence-based recommendations should
be regarded as a crucial step in the global fight against antimicrobial resistance. Within this …
be regarded as a crucial step in the global fight against antimicrobial resistance. Within this …
Acinetobacter baumannii Bacteriophage: Progress in Isolation, Genome Sequencing, Preclinical Research, and Clinical Application
Y Li, S Xiao, G Huang - Current Microbiology, 2023 - Springer
Acinetobacter baumannii (A. baumannii) is a common nosocomial pathogen associated with
serious clinical challenges owing to its rapidly increasing resistance to antibiotics. Due to …
serious clinical challenges owing to its rapidly increasing resistance to antibiotics. Due to …
Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions
N Morales-Durán, A León-Buitimea… - Heliyon, 2024 - cell.com
Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are
the main drivers in developing drug-resistant bacteria. The emergence of the rapid global …
the main drivers in developing drug-resistant bacteria. The emergence of the rapid global …
Exploring the antimicrobial potential of crude peptide extracts from Allium sativum and Allium oschaninii against antibiotic-resistant bacterial strains
T Swangsri, O Reamtong, S Saralamba… - Pharmaceutical …, 2024 - Taylor & Francis
Context Plant peptides garner attention for their potential antimicrobial properties amid the
rising concern over antibiotic-resistant bacteria. Objective This study investigates the …
rising concern over antibiotic-resistant bacteria. Objective This study investigates the …
Biological Control of Acinetobacter baumannii: In Vitro and In Vivo Activity, Limitations, and Combination Therapies
The survival, proliferation, and epidemic spread of Acinetobacter baumannii (A. baumannii)
in hospital settings is associated with several characteristics, including resistance to many …
in hospital settings is associated with several characteristics, including resistance to many …
An optimal antibiotic selection framework for Sepsis patients using Artificial Intelligence
P Wendland, C Schenkel-Häger, I Wenningmann… - npj Digital …, 2024 - nature.com
In this work we present OptAB, the first completely data-driven online-updateable antibiotic
selection model based on Artificial Intelligence for Sepsis patients accounting for side …
selection model based on Artificial Intelligence for Sepsis patients accounting for side …