Small-molecule antibiotic drug development: need and challenges

M Bergkessel, B Forte, IH Gilbert - ACS Infectious Diseases, 2023 - ACS Publications
The need for new antibiotics is urgent. Antimicrobial resistance is rising, although currently,
many more people die from drug-sensitive bacterial infections. The continued evolution of …

All-cause mortality rates in adults with carbapenem-resistant Gram-negative bacterial infections: a comprehensive review of pathogen-focused, prospective …

TP Lodise, M Bassetti, R Ferrer, T Naas… - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction Pathogen-focused, randomized, controlled trials (PF-RCT) are important in the
fight against carbapenem-resistant (CR) Gram-negative infections. Some recently approved …

The case against antibiotics and for anti-virulence therapeutics

JA Hotinger, ST Morris, AE May - Microorganisms, 2021 - mdpi.com
Although antibiotics have been indispensable in the advancement of modern medicine,
there are downsides to their use. Growing resistance to broad-spectrum antibiotics is …

Systematic Review of Antimicrobial Combination Options for Pandrug-Resistant Acinetobacter baumannii

S Karakonstantis, P Ioannou, G Samonis, DP Kofteridis - Antibiotics, 2021 - mdpi.com
Antimicrobial combinations are at the moment the only potential treatment option for
pandrug-resistant A. baumannii. A systematic review was conducted in PubMed and Scopus …

How to tailor recommendations on the treatment of multi-drug resistant Gram-negative infections at country level integrating antibiotic stewardship principles within the …

E Carrara, PA Grossi, A Gori… - The Lancet Infectious …, 2024 - thelancet.com
Promoting the optimal use of antibiotics through evidence-based recommendations should
be regarded as a crucial step in the global fight against antimicrobial resistance. Within this …

Acinetobacter baumannii Bacteriophage: Progress in Isolation, Genome Sequencing, Preclinical Research, and Clinical Application

Y Li, S Xiao, G Huang - Current Microbiology, 2023 - Springer
Acinetobacter baumannii (A. baumannii) is a common nosocomial pathogen associated with
serious clinical challenges owing to its rapidly increasing resistance to antibiotics. Due to …

Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

N Morales-Durán, A León-Buitimea… - Heliyon, 2024 - cell.com
Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are
the main drivers in developing drug-resistant bacteria. The emergence of the rapid global …

Exploring the antimicrobial potential of crude peptide extracts from Allium sativum and Allium oschaninii against antibiotic-resistant bacterial strains

T Swangsri, O Reamtong, S Saralamba… - Pharmaceutical …, 2024 - Taylor & Francis
Context Plant peptides garner attention for their potential antimicrobial properties amid the
rising concern over antibiotic-resistant bacteria. Objective This study investigates the …

Biological Control of Acinetobacter baumannii: In Vitro and In Vivo Activity, Limitations, and Combination Therapies

B Havenga, B Reyneke, M Waso-Reyneke, T Ndlovu… - Microorganisms, 2022 - mdpi.com
The survival, proliferation, and epidemic spread of Acinetobacter baumannii (A. baumannii)
in hospital settings is associated with several characteristics, including resistance to many …

An optimal antibiotic selection framework for Sepsis patients using Artificial Intelligence

P Wendland, C Schenkel-Häger, I Wenningmann… - npj Digital …, 2024 - nature.com
In this work we present OptAB, the first completely data-driven online-updateable antibiotic
selection model based on Artificial Intelligence for Sepsis patients accounting for side …