At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Autophagy is a highly coordinated process that is controlled at several levels including
transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear …

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

Alzheimer disease (AD) is characterized by the accumulation of amyloid plaques, which are
predominantly composed of amyloid-β peptide. Two principal physiological pathways either …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Alzheimer's disease (AD) is characterized by a progressive dysfunction of central neurons.
Recent experimental evidence indicates that in the cortex, in addition to the silencing of a …

The regulation of physiological gut functions such as peristalsis or secretion of digestive
enzymes by the central nervous system via the Nervus vagus is well known. Recent …

Peptides or proteins convert under some conditions from their soluble forms into highly
ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging …