Although the genetic landscape of chronic lymphocytic leukemia (CLL) has been broadly
profiled by large-scale sequencing studies performed over the past decade, the molecular …

Richter transformation (RT) refers to the progression of chronic lymphocytic leukemia, the
most prevalent leukemia among adults, into a highly aggressive lymphoproliferative …

Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an
aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …

Somatic mutations accumulate in all cells with age and can confer a selective advantage,
leading to clonal expansion over time. In hematopoietic cells, mutations in a subset of genes …

Chronic lymphocytic leukemia (CLL) is a B-cell neoplasm with a heterogeneous clinical
behavior. In 5–10% of patients the disease transforms into a diffuse large-B cell lymphoma …

Loss-of-function mutations in NFKBIE, which encodes for the NF-κB inhibitor IκBε, are
frequent in chronic lymphocytic leukemia (CLL) and certain other B-cell malignancies and …

Transformation to aggressive disease histologies generates formidable clinical challenges
across cancers, but biological insights remain few. We modeled the genetic heterogeneity of …

Genetic diagnostics of hematological malignancies has evolved dramatically over the years,
from chromosomal banding analysis to next-generation sequencing, with a corresponding …

Genetic testing has been applied for decades in clinical routine diagnostics of hematological
malignancies to improve disease (sub) classification, prognostication, patient management …