Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Biocatalysis is currently undergoing a profound transformation. The field moves from relying
on nature's chemical logic to a discipline that exploits generic activation modes, allowing for …

Enzyme-catalyzed stereodivergent synthesis to access all possible stereoisomers of
organofluorine compounds bearing multiple stereogenic centers remains an important and …

Biocatalysis using (recombinant) enzymes is gaining traction as a method for selective
chemical catalysis, especially in the pharmaceutical industry. Flow systems, especially …

3-Hydroxyindolenines can be used to access several structural motifs that are featured in
natural products and pharmaceutical compounds, yet the chemical synthesis of 3 …

The properties of natural products can be significantly influenced by glycosylation,
emphasizing the key role of glycosyltransferases (GTs) in this process. The pursuit of …

Bacterial natural products (BNPs) are very important sources of leads for drug development
and chemical novelty. The possibility to perform late-stage diversification of BNPs using …

Macrocyclization reactions that are capable of stereoselectively co-creating one or more
stereogenic centers have become useful strategies for the effective syntheses of structurally …

Biocatalysis has entered its Golden Age 1 with increasing adoption in organic chemistry, 2
pharmaceutical research and development, 3 and exciting new applications in …

Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans and the
cell walls of fungi, have garnered considerable attention in pharmaceutical circles due to …