[HTML][HTML] Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
Alzheimer's disease
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …
Microglia phenotypes in aging and neurodegenerative diseases
MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …
fundamental role in mediating the onset and progression of disease. Microglia, which …
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?
Alzheimer's disease (AD) is characterized by extracellular aggregates of amyloid β peptides,
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …
Alzheimer's disease: an update and insights into pathophysiology
Alzheimer's disease (AD) is an irreversible brain disorder associated with slow, progressive
loss of brain functions mostly in older people. The disease processes start years before the …
loss of brain functions mostly in older people. The disease processes start years before the …
[HTML][HTML] An in vivo neuroimmune organoid model to study human microglia phenotypes
Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …
development, homeostasis, and disease. However, until now, the ability to model …
Cellular senescence at the crossroads of inflammation and Alzheimer's disease
A Guerrero, B De Strooper… - Trends in …, 2021 - cell.com
Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease
The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has
accelerated research into the role of microglia in AD. While TREM2 mouse models have …
accelerated research into the role of microglia in AD. While TREM2 mouse models have …
[HTML][HTML] Microglia require CD4 T cells to complete the fetal-to-adult transition
The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …
the central nervous system, their presence in the healthy brain remains controversial, and …