Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation
JR Liu, H Miao, DQ Deng, ND Vaziri, P Li… - Cellular and Molecular …, 2021 - Springer
The gut microbiota has a crucial effect on regulating the intestinal mucosal immunity and
maintaining intestinal homeostasis both in health and in disease state. Many effects are …
maintaining intestinal homeostasis both in health and in disease state. Many effects are …
MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer
N Venkateswaran, MC Lafita-Navarro… - Genes & …, 2019 - genesdev.cshlp.org
Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly
proliferating cancer cells. Seminal studies have shown that the proto-oncogene MYC …
proliferating cancer cells. Seminal studies have shown that the proto-oncogene MYC …
AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2. 5 in zebrafish embryos
F Ren, C Ji, Y Huang, S Aniagu, Y Jiang… - Science of the Total …, 2020 - Elsevier
Recent studies have shown an association between maternal exposure to ambient fine
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …
AHR/ROS-mediated mitochondria apoptosis contributes to benzo [a] pyrene-induced heart defects and the protective effects of resveratrol
Y Huang, J Zhang, Y Tao, C Ji, S Aniagu, Y Jiang… - Toxicology, 2021 - Elsevier
Abstract Benzo [a] pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon, is widely
present in the environment. BaP-induced heart defects have been frequently reported, but …
present in the environment. BaP-induced heart defects have been frequently reported, but …
The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling
A Luo, Z Wu, S Li, CB McReynolds, D Wang… - Journal of translational …, 2023 - Springer
Background Patients suffering from chronic pain often also exhibit depression symptoms.
Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory …
Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory …
Aryl hydrocarbon receptor (AhR) activation contributes to high‐fat diet‐induced vascular dysfunction
JF da Silva, JA Bolsoni, RM da Costa… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Metabolic and vascular dysfunction are common features of
obesity. Aryl hydrocarbon receptor (AhR) regulates lipid metabolism and vascular …
obesity. Aryl hydrocarbon receptor (AhR) regulates lipid metabolism and vascular …
[HTML][HTML] Polyphenol and glucosinolate-derived AhR modulators regulate GPR15 expression on human CD4+ T cells
JS Tang, R Stephens, Y Li, A Cait, K Gell… - The Journal of …, 2023 - Elsevier
Diets high in fruit and vegetables are perceived to be beneficial for intestinal homeostasis, in
health as well as in the context of inflammatory bowel diseases (IBDs). Recent …
health as well as in the context of inflammatory bowel diseases (IBDs). Recent …
An endogenous ligand of aryl hydrocarbon receptor 6-formylindolo [3, 2-b] carbazole (FICZ) is a signaling molecule in neurogenesis of adult hippocampal neurons
M Keshavarzi, MJ Khoshnoud… - Journal of Molecular …, 2020 - Springer
Neurogenesis is a dynamic and physiologic developmental process that affects learning and
hippocampal dependent memory. It is regulated by multi-cellular micro-environment and …
hippocampal dependent memory. It is regulated by multi-cellular micro-environment and …
The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress
N Guerrina, N Aloufi, F Shi, K Prasade… - … of Physiology-Lung …, 2021 - journals.physiology.org
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose
physiological function is poorly understood. The AhR is highly expressed in barrier organs …
physiological function is poorly understood. The AhR is highly expressed in barrier organs …
The interplay of aryl hydrocarbon receptor/WNT/CTNNB1/Notch signaling pathways regulate amyloid beta precursor mRNA/protein expression and effected the …
M Keshavarzi, F Moradbeygi, K Mobini… - Toxicology …, 2022 - academic.oup.com
The amyloid beta precursor protein (APP) plays a pathophysiological role in the
development of Alzheimer's disease as well as a physiological role in neuronal growth and …
development of Alzheimer's disease as well as a physiological role in neuronal growth and …