The gut microbiota has a crucial effect on regulating the intestinal mucosal immunity and
maintaining intestinal homeostasis both in health and in disease state. Many effects are …

Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly
proliferating cancer cells. Seminal studies have shown that the proto-oncogene MYC …

Recent studies have shown an association between maternal exposure to ambient fine
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …

Abstract Benzo [a] pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon, is widely
present in the environment. BaP-induced heart defects have been frequently reported, but …

Background Patients suffering from chronic pain often also exhibit depression symptoms.
Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory …

Background and Purpose Metabolic and vascular dysfunction are common features of
obesity. Aryl hydrocarbon receptor (AhR) regulates lipid metabolism and vascular …

Diets high in fruit and vegetables are perceived to be beneficial for intestinal homeostasis, in
health as well as in the context of inflammatory bowel diseases (IBDs). Recent …

Neurogenesis is a dynamic and physiologic developmental process that affects learning and
hippocampal dependent memory. It is regulated by multi-cellular micro-environment and …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose
physiological function is poorly understood. The AhR is highly expressed in barrier organs …

The amyloid beta precursor protein (APP) plays a pathophysiological role in the
development of Alzheimer's disease as well as a physiological role in neuronal growth and …