Inflammatory responses arise as an outcome of tissues or organs exposure towards harmful
stimuli like injury, toxic chemicals or pathogenic microorganism. It is a complex cascade of …

Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …

Objectives Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is
caused by TNFRSF1A mutations, known to induce intracellular retention of the TNFα …

There is a thriving interest in the field of hereditary autoinflammatory disorders (HAID), a
gamut of heterogeneous conditions deriving from an aberrant orchestration of innate …

Autoinflammatory diseases are genetic or acquired clinical entities globally caused by the
aberrant release of the proinflammatory cytokine interleukin-1 and mostly characterized by …

Autoinflammatory diseases are comprehensively caused by aberrant production of
proinflammatory cytokines and are revealed by cyclically and spontaneously occurring …

Background Somatic mosaicism is to date an uncommon finding in genetic autoinflammatory
syndromes such as Cryopyrin‐associated periodic syndrome, Blau syndrome, and TNF …

Abstract Interleukin-1beta (IL-1β) is an ancient and evolutionary conserved cytokine, which
orchestrates innate immune responses triggered by infections in vertebrates. While …

Type 2 diabetes is a chronic metabolic disorder, where failure to maintain normal glucose
homoeostasis is associated with, and exacerbated by, obesity and the concomitant-elevated …

Cytokines are secreted from macrophages and other cells of the immune system in
response to pathogens. Additionally, in autoinflammatory diseases cytokine secretion occurs …