DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and
in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is …

Human Dual specificity tyrosine (Y)-Regulated Kinase 1A (DYRK1A) is encoded by a
dosage-dependent gene located in the Down syndrome critical region of human …

Aims/hypothesis Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors
of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone …

Corticosteroids are potent anti-inflammatory agents, but corticosteroid insensitivity is a major
barrier for the treatment of some chronic inflammatory diseases. Here, we show that hypoxia …

Definitive identification of promoters, their cis-regulatory motifs, and their trans-acting
proteins requires experimental analysis. To define the HNRNPK promoter and its cognate …

Background In the process of retrotransposition LINEs use their own machinery for copying
and inserting themselves into new genomic locations, while SINEs are parasitic and require …

How TATA-less promoters such as those within CpG islands (CGI) control gene expression
is still a subject of active research. Here, we have identified the “CGCG element”, a ten-base …

Background Health disparities and the high prevalence of cardiovascular disease continue
to be perplexing worldwide health challenges. This study addresses the possibility that …

Transcription initiation involves the recruitment of basal transcription factors to the core
promoter. A variety of core promoter elements exists; however for most of these motifs, the …

We present here a neural network-based method for detection of signal peptides
(abbreviation used: SP) in proteins. The method is trained on sequences of known signal …