Anti-tuberculosis drugs are a two-edged sword. While they destroy pathogenic M.
tuberculosis they also select for drug resistant bacteria against which those drugs are then …

Tuberculosis (TB) is a major infectious disease killing nearly two million people, mostly in
developing countries, every year. The increasing incidence of resistance of Mycobacterium …

The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex.
Putative isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and …

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available
antibiotics, and requires new approaches to antibiotic discovery and development …

Vietnam is ranked 13th among the WHO list of 22 high-burden countries, based upon
estimated total number of tuberculosis cases. Despite having a model national tuberculosis …

Mutations at position 306 of embB (embB 306) have been proposed as a marker for
ethambutol resistance in Mycobacterium tuberculosis; however, recent reports of embB 306 …

Background Drug resistance displays a problem for the therapy of Mycobacterium
tuberculosis infections. For molecular resistance testing, it is essential to have precise …

Abstract Background Introduction of Xpert® MTB/RIF assay has revolutionalised the
diagnosis of tuberculosis (TB) by simultaneously detecting the bacteria and resistance to …

One-third of the world's population is infected with Mycobacterium (M.) tuberculosis.
Tuberculosis continues to be the most common infectious cause of death and still has a …

Combining multiplex PCR, sequentially, with reverse line blot hybridization (mPCR/RLB) is a
convenient, objective way to identify up to 43 targets in 43 individual specimens …