Asthma is a complex inflammatory disease characterized by airway inflammation and
hyperresponsiveness. The mechanisms associated with the development and progression …

NF-kappa B is a ubiquitous transcription factor. Nevertheless, its properties seem to be most
extensively exploited in cells of the immune system. Among these properties are NF-kappa …

Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-κB/IκB) complex leading to its
activation, NF-κB translocation into the nucleus, DNA binding, and transactivation have been …

The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed
by several cell types, including leukocytes and endothelial cells. It can be induced in a cell …

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB
and Steroid Receptor-Signaling Pathways | Endocrine Reviews | Oxford Academic Skip to …

NF-KB, a heterodimeric transcription factor composed of p50 and p65 subunits, can be
activated in many cell types and is thought to regulate a wide variety of genes involved in …

Oxidative stress and the production of intracellular reactive oxygen species (ROS) have
been implicated in the pathogenesis of a variety of diseases. In excess, ROS and their …

INDUCIBLE gene expression in eukaryotes is mainly controlled by the activity of
transcriptional activator proteins, such as NF-κB (refs 1–3), a factor activated upon treatment …

Interleukin (IL) 12 is a proinflammatory cytokine produced by phagocytic cells, B cells, and
other antigen-presenting cells that modulates adaptive immune responses by favoring the …

The Rho family of small GTPases are critical elements involved in the regulation of signal
transduction cascades from extracellular stimuli to the cell nucleus, including the JNK/SAPK …