Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets
V Mishra, J Banga, P Silveyra - Pharmacology & Therapeutics, 2018 - Elsevier
Asthma is a complex inflammatory disease characterized by airway inflammation and
hyperresponsiveness. The mechanisms associated with the development and progression …
hyperresponsiveness. The mechanisms associated with the development and progression …
Function and activation of NF-kappa B in the immune system.
PA Baeuerle, T Henkel - Annual review of immunology, 1994 - europepmc.org
NF-kappa B is a ubiquitous transcription factor. Nevertheless, its properties seem to be most
extensively exploited in cells of the immune system. Among these properties are NF-kappa …
extensively exploited in cells of the immune system. Among these properties are NF-kappa …
Redox regulation of NF-kappa B activation
L Flohé, R Brigelius-Flohé, C Saliou, MG Traber… - Free Radical Biology …, 1997 - Elsevier
Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-κB/IκB) complex leading to its
activation, NF-κB translocation into the nucleus, DNA binding, and transactivation have been …
activation, NF-κB translocation into the nucleus, DNA binding, and transactivation have been …
Intercellular adhesion molecule-1
A Van de Stolpe, PT Van der Saag - Journal of molecular medicine, 1996 - Springer
The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed
by several cell types, including leukocytes and endothelial cells. It can be induced in a cell …
by several cell types, including leukocytes and endothelial cells. It can be induced in a cell …
Molecular control of immune/inflammatory responses: interactions between nuclear factor-κB and steroid receptor-signaling pathways
LI McKay, JA Cidlowski - Endocrine reviews, 1999 - academic.oup.com
Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB
and Steroid Receptor-Signaling Pathways | Endocrine Reviews | Oxford Academic Skip to …
and Steroid Receptor-Signaling Pathways | Endocrine Reviews | Oxford Academic Skip to …
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
CS William, HC Liou, EI Tuomanen, D Baltimore - Cell, 1995 - cell.com
NF-KB, a heterodimeric transcription factor composed of p50 and p65 subunits, can be
activated in many cell types and is thought to regulate a wide variety of genes involved in …
activated in many cell types and is thought to regulate a wide variety of genes involved in …
Oxidative stress as a regulator of gene expression in the vasculature
C Kunsch, RM Medford - Circulation research, 1999 - Am Heart Assoc
Oxidative stress and the production of intracellular reactive oxygen species (ROS) have
been implicated in the pathogenesis of a variety of diseases. In excess, ROS and their …
been implicated in the pathogenesis of a variety of diseases. In excess, ROS and their …
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
T Henkel, T Machleidt, I Alkalay, M Krönke… - Nature, 1993 - nature.com
INDUCIBLE gene expression in eukaryotes is mainly controlled by the activity of
transcriptional activator proteins, such as NF-κB (refs 1–3), a factor activated upon treatment …
transcriptional activator proteins, such as NF-κB (refs 1–3), a factor activated upon treatment …
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
Interleukin (IL) 12 is a proinflammatory cytokine produced by phagocytic cells, B cells, and
other antigen-presenting cells that modulates adaptive immune responses by favoring the …
other antigen-presenting cells that modulates adaptive immune responses by favoring the …
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.
R Perona, S Montaner, L Saniger… - Genes & …, 1997 - genesdev.cshlp.org
The Rho family of small GTPases are critical elements involved in the regulation of signal
transduction cascades from extracellular stimuli to the cell nucleus, including the JNK/SAPK …
transduction cascades from extracellular stimuli to the cell nucleus, including the JNK/SAPK …