Identifying neoantigens for use in immunotherapy
S Hutchison, AL Pritchard - Mammalian Genome, 2018 - Springer
This review focuses on the types of cancer antigens that can be recognised by the immune
system and form due to alterations in the cancer genome, including cancer testis …
system and form due to alterations in the cancer genome, including cancer testis …
NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction
Background The major histocompatibility complex (MHC) molecule plays a central role in
controlling the adaptive immune response to infections. MHC class I molecules present …
controlling the adaptive immune response to infections. MHC class I molecules present …
Major histocompatibility complex linked databases and prediction tools for designing vaccines
Presently, the major histocompatibility complex (MHC) is receiving considerable interest
owing to its remarkable role in antigen presentation and vaccine design. The specific …
owing to its remarkable role in antigen presentation and vaccine design. The specific …
TAA polyepitope DNA‐based vaccines: A potential tool for cancer therapy
R Bei, A Scardino - BioMed Research International, 2010 - Wiley Online Library
DNA‐based cancer vaccines represent an attractive strategy for inducing immunity to tumor
associated antigens (TAAs) in cancer patients. The demonstration that the delivery of a …
associated antigens (TAAs) in cancer patients. The demonstration that the delivery of a …
Dana-Farber repository for machine learning in immunology
The immune system is characterized by high combinatorial complexity that necessitates the
use of specialized computational tools for analysis of immunological data. Machine learning …
use of specialized computational tools for analysis of immunological data. Machine learning …
Computational characterization of Plasmodium falciparum proteomic data for screening of potential vaccine candidates
Advancement in the field of proteomics and bioinformatics offers tremendous opportunities
for the development of novel epitope-based effective vaccine against human malaria. In this …
for the development of novel epitope-based effective vaccine against human malaria. In this …
Targeting neoantigens for personalised immunotherapy
AL Pritchard - BioDrugs, 2018 - Springer
This review discusses the rapidly evolving field of immunotherapy research, focusing on the
types of cancer antigens that can be recognised by the immune system and potential …
types of cancer antigens that can be recognised by the immune system and potential …
Improved prediction of MHC class I binders/non-binders peptides through artificial neural network using variable learning rate: SARS corona virus, a case study
Fundamental step of an adaptive immune response to pathogen or vaccine is the binding of
short peptides (also called epitopes) to major histocompatibility complex (MHC) molecules …
short peptides (also called epitopes) to major histocompatibility complex (MHC) molecules …
Computational screening and characterization of putative vaccine candidates of Plasmodium vivax
Y Nanda Kumar, G Jeyakodi… - Journal of …, 2016 - Taylor & Francis
Plasmodium vivax is the most prevalent species of malaria affecting millions of people
annually worldwide and demands effective interventions to develop a successful vaccine. In …
annually worldwide and demands effective interventions to develop a successful vaccine. In …
Modern Developments in Short Peptide Viral Vaccine Design
C Nilofer, M Arumugam, P Kangueane - Global Virology III: Virology in the …, 2019 - Springer
Vaccine design and development against viral diseases is multifaceted. Classical vaccines
(live-attenuated vaccines, inactivated vaccines, subunit, recombinant, polysaccharide …
(live-attenuated vaccines, inactivated vaccines, subunit, recombinant, polysaccharide …