Publisher Summary This chapter summarizes the experimental findings and observations
based on the nonobese diabetic (NOD) mouse model and discusses the pathogenesis and …

The nonobese diabetic (NOD) mouse is a model of human autoimmune insulin-dependent
diabetes mellitus. The NOD mouse also serves as a model for studying complex polygenic …

The advent of complete genetic linkage maps consisting of codominant DNA markers
[typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …

The dynamics of CD4+ effector T cells (Teff cells) and CD4+ Foxp3+ regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine …

Ataxia-telangiectasia (AT) is a human autosomal recessive disorder of childhood1, 2
characterized by:(1) progressive cerebellar ataxia with degeneration of Purkinje cells;(2) …

Dextran sulfate sodium (DSS)-induced murine colitis represents an experimental model for
human inflammatory bowel disease. The aim of this study was to screen various inbred …

Autoreactive CD4+ T cells are involved in the pathogenesis of many autoimmune diseases,
but the antigens that stimulate their responses have been difficult to identify and in most …

The ability to discriminate between self and nonself antigens is vital to the functioning of the
immune system as a specific defense against invading microorganisms. Failure of the …

Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These
cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus …