Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data
The blood–brain barrier (BBB) excludes the vast majority of cancer therapeutics from normal
brain. However, the importance of the BBB in limiting drug delivery and efficacy is …
brain. However, the importance of the BBB in limiting drug delivery and efficacy is …
Emerging applications of artificial intelligence in neuro-oncology
Due to the exponential growth of computational algorithms, artificial intelligence (AI)
methods are poised to improve the precision of diagnostic and therapeutic methods in …
methods are poised to improve the precision of diagnostic and therapeutic methods in …
Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing
(NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present …
(NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present …
Radiogenomics to characterize regional genetic heterogeneity in glioblastoma
Background Glioblastoma (GBM) exhibits profound intratumoral genetic heterogeneity. Each
tumor comprises multiple genetically distinct clonal populations with different therapeutic …
tumor comprises multiple genetically distinct clonal populations with different therapeutic …
Imaging correlates of adult glioma genotypes
M Smits, MJ van den Bent - Radiology, 2017 - pubs.rsna.org
Primary brain tumors, most commonly gliomas, are histopathologically typed and graded as
World Health Organization (WHO) grades I–IV according to increasing degrees of …
World Health Organization (WHO) grades I–IV according to increasing degrees of …
Gliomas: Histogram Analysis of Apparent Diffusion Coefficient Maps with Standard- or High-b-Value Diffusion-weighted MR Imaging—Correlation with Tumor Grade
Purpose To explore the role of histogram analysis of apparent diffusion coefficient (ADC)
maps based on entire tumor volume data in determining glioma grade and to evaluate the …
maps based on entire tumor volume data in determining glioma grade and to evaluate the …
MR guidance in radiotherapy
JJW Lagendijk, BW Raaymakers… - Physics in Medicine …, 2014 - iopscience.iop.org
The use of modern MRI technology in radiotherapy is fast growing. MRI is entering all facets
of radiotherapy. This review will start with a very short overview of the newest developments …
of radiotherapy. This review will start with a very short overview of the newest developments …
MR fingerprinting of adult brain tumors: initial experience
C Badve, A Yu, S Dastmalchian… - American Journal …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: MR fingerprinting allows rapid simultaneous quantification
of T1 and T2 relaxation times. This study assessed the utility of MR fingerprinting in …
of T1 and T2 relaxation times. This study assessed the utility of MR fingerprinting in …
Imaging of intratumoral heterogeneity in high-grade glioma
Abstract High-grade glioma (HGG), and particularly Glioblastoma (GBM), can exhibit
pronounced intratumoral heterogeneity that confounds clinical diagnosis and management …
pronounced intratumoral heterogeneity that confounds clinical diagnosis and management …
Multimodality brain tumor imaging: MR imaging, PET, and PET/MR imaging
JR Fink, M Muzi, M Peck, KA Krohn - Journal of Nuclear Medicine, 2015 - Soc Nuclear Med
Standard MR imaging and CT are routinely used for anatomic diagnosis in brain tumors.
Pretherapy planning and posttreatment response assessments rely heavily on gadolinium …
Pretherapy planning and posttreatment response assessments rely heavily on gadolinium …