In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Specialized receptors that recognize molecular patterns such as double stranded RNA
duplexes—indicative of viral replication—are potent triggers of the innate immune system …

Conclusions Our findings indicate that LINC00665 is involved in the NF‐κB signaling
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

TRAF6 is a ubiquitin ligase that is essential for the activation of NF-κB and MAP kinases in
several signalling pathways, including those emanating from the interleukin 1 and Toll-like …

The IFN-induced double-stranded RNA-dependent protein kinase (PKR) is one of the four
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …

The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65–70
amino acids adopting an αβββα fold, whose central property is to bind to double-stranded …

Mammalian cells respond to dsRNA in multiple manners. One key response to dsRNA is the
activation of PKR, an eIF2α kinase, which triggers translational arrest and the formation of …

The antiviral protein kinase PKR inhibits protein synthesis by phosphorylating the translation
initiation factor eIF2α on Ser51. Binding of double-stranded RNA to the regulatory domains …