Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

Mutations that target the ubiquitous process of ribosome assembly paradoxically cause
diverse tissue-specific disorders (ribosomopathies) that are often associated with an …

SBDS protein (deficient in the inherited leukemia-predisposition disorder Shwachman-
Diamond syndrome) and the GTPase EFL1 (an EF-G homolog) activate nascent 60S …

Ribosome assembly is required for cell growth in all organisms. Classic in vitro work in
bacteria has led to a detailed understanding of the biophysical, thermodynamic, and …

Wobble uridines (U34) are generally modified in all species. U34 modifications can be
essential in metazoans but are not required for viability in fungi. In this review, we provide an …

Ribosomes and spliceosomes are ribonucleoprotein nanomachines that catalyze translation
of mRNA to synthesize proteins and splicing of introns from pre-mRNAs, respectively …

Casein kinase 1δ/ε (CK1δ/ε) and their yeast homologue Hrr25 are essential for cell growth.
Further, CK1δ is overexpressed in several malignancies, and CK1δ inhibitors have shown …

Autophagy is the major pathway for the delivery of cytoplasmic material to the vacuole or
lysosome. Selective autophagy is mediated by cargo receptors, which link the cargo to the …

Transfer RNA (tRNA) is subject to a multitude of posttranscriptional modifications which can
profoundly impact its functionality as the essential adaptor molecule in messenger RNA …

Here we discuss the function of eukaryotic initiation factor 6 (eIF6; Tif6 in yeast). eIF6 binds
60S ribosomal subunits and blocks their joining to 40S. In this context, we propose that eIF6 …