CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and
regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with …

Tumour progression is dependent on the interaction between tumour cells and cells of the
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …

Since its first description more than 20 years ago osteopontin has emerged as an active
player in many physiological and pathological processes, including biomineralization, tissue …

In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its
role in bone remodeling and orthodontic tooth movement are discussed based on available …

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN
is involved in normal physiological processes and is implicated in the pathogenesis of a …

The dynamic nature of the skeleton is achieved by a process called “remodeling” which
involves the co-ordinated actions of osteoclasts, osteoblasts, osteocytes within the bone …

Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory
and autoimmune diseases, and it is specifically localized in and around inflammatory cells …

Cell migration and degradation of the extracellular matrix (ECM) are crucial steps in tumor
progression. Several matrix-degrading proteases, including matrix metalloproteases, are …

The extracellular matrix (ECM) plays an important role in the regulation of the tissue
microenvironment and in the maintenance of cellular homeostasis. Several proteins with a …

Background Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-
negative bacteria's outer membrane. During gram-negative bacterial sepsis, LPS regulates …