Chemistry of MRI contrast agents: current challenges and new frontiers
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …
performed annually around the world. The contrast agents, which improve diagnostic …
Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …
strong resistance to therapy, leading to the poor prognosis in several cancer types …
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to
its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide …
its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide …
Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy
Hypoxia not only promotes tumor metastasis but also strengthens tumor resistance to
therapies that demand the involvement of oxygen, such as radiation therapy and …
therapies that demand the involvement of oxygen, such as radiation therapy and …
Nano-ROS-generating approaches to cancer dynamic therapy: lessons from nanoparticles
Q Zhang, Q Luo, Z Liu, M Sun, X Dong - Chemical Engineering Journal, 2023 - Elsevier
Reactive oxygen species (ROS)-based dynamic cancer therapies are therapeutic modalities
of endogenous/exogenous-responsive intratumoral ROS generation, including …
of endogenous/exogenous-responsive intratumoral ROS generation, including …
MnO2 gatekeeper: an intelligent and O2‐evolving shell for preventing premature release of high cargo payload core, overcoming tumor hypoxia, and acidic H2O2 …
Premature leakage of photosensitizer (PS) from nanocarriers significantly reduces the
accumulation of PS within a tumor, thereby enhancing nonspecific accumulation in normal …
accumulation of PS within a tumor, thereby enhancing nonspecific accumulation in normal …
Breaking the depth dependence by nanotechnology‐enhanced X‐ray‐excited deep cancer theranostics
The advancements in nanotechnology have created multifunctional nanomaterials aimed at
enhancing diagnostic accuracy and treatment efficacy for cancer. However, the ability to …
enhancing diagnostic accuracy and treatment efficacy for cancer. However, the ability to …
Red blood cell‐facilitated photodynamic therapy for cancer treatment
Photodynamic therapy (PDT) is a promising treatment modality for cancer management. So
far, most PDT studies have focused on delivery of photosensitizers to tumors. O2, another …
far, most PDT studies have focused on delivery of photosensitizers to tumors. O2, another …
Stable and inert Mn (II)-based and pH-responsive contrast agents
R Botár, E Molnár, G Trencsényi, J Kiss… - Journal of the …, 2020 - ACS Publications
Smart/intelligent contrast agent candidates for MRI based on Mn (II) ion are rare, as it usually
forms labile complexes with polyaminocarboxylate-type ligands. Here, we report the first …
forms labile complexes with polyaminocarboxylate-type ligands. Here, we report the first …