The chromosomal region, 15q11-q13, involved in Prader-Willi and Angelman syndromes
(PWS and AS) represents a paradigm for understanding the relationships between genome …

A cluster of low copy repeats on the proximal long arm of chromosome 15 mediates various
forms of stereotyped deletions and duplication events that cause a group of …

Since the identification of the first MAGE gene in 1991, the MAGE family has expanded
dramatically, and over 25 MAGE genes have now been identified in humans. The focus of …

Prader–Willi syndrome (PWS) is a complex neurogenetic disorder with considerable clinical
variability that is thought in large part to be the result of a hypothalamic defect. PWS results …

Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent‐of‐
origin‐dependent monoallelic expression in the offspring. Embryological and classical …

Imprinted genes are expressed monoallelically depending on their parental origin. High
expression of the majority of imprinted genes tested to date has been demonstrated in …

Prader-Willi syndrome (PWS) is an imprinted genetic obesity disorder characterized by
abnormalities of growth and metabolism. Multiple mouse models with deficiency of one or …

Imprinted ncRNA (non‐coding RNA) genes represent a family of untranslated transcripts that
are mono‐allelically expressed in a parent‐of‐origin manner (their expression is restricted to …

Prader-Willi syndrome (PWS [MIM 176270]) is a neurogenetic disorder characterized by
decreased fetal activity, muscular hypotonia, failure to thrive, short stature, obesity, mental …

Prader-Willi syndrome (PWS) is a complex neurogenetic disorder. The phenotype is likely to
be a contiguous gene syndrome involving genes which are paternally expressed only …