In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …

Termination of protein synthesis is not 100% efficient. A number of natural mechanisms that
suppress translation termination exist. One of them is STOP codon readthrough, the process …

Summary Nonsense mutations, accounting for> 20% of disease-associated mutations, lead
to premature translation termination. Replacing uridine with pseudouridine in stop codons …

Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redox
balance. Peroxisomal function is central to fatty acid oxidation, ether phospholipid synthesis …

Nonsense‐mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control
process that serves both as a mechanism to eliminate aberrant transcripts carrying …

Peroxisomes carry out many key functions related to lipid and reactive oxygen species
(ROS) metabolism. The fundamental importance of peroxisomes for health in humans is …

Abstract The development of Ribosome Profiling (RiboSeq) has revolutionized functional
genomics. RiboSeq is based on capturing and sequencing of the mRNA fragments enclosed …

During canonical translation, the ribosome moves along an mRNA from the start to the stop
codon in exact steps of one codon at a time. The collinearity of the mRNA and the protein …

About 11% of all human disease-associated gene lesions are nonsense mutations, resulting
in the introduction of an in-frame premature translation-termination codon (PTC) into the …

Yeasts and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR)
orthologs and are believed to lack A-to-I RNA editing, which is the most prevalent editing of …