The dipeptide carnosine has been observed to exert antiaging activity at cellular and whole
animal levels. This review discusses the possible mechanisms by which carnosine may …

Transglutaminase (TGase, EC 2.3. 2.13) catalyzes acyl transfer reactions between the γ-
carboxamide groups of protein-bound glutamine (Gln) residues, which serve as acyl donors …

Reactive oxygen species, reactive nitrogen species, copper and zinc ions, glycating agents
and reactive aldehydes, protein cross-linking and proteolytic dysfunction may all contribute …

Altered gene expression occurs in central nervous system disorders, including Alzheimer's
disease (AD). Transcription factor Sp1 may be involved insofar as it can regulate the …

Carnosine is an endogenous dipeptide abundant in the central nervous system, where by
acting as intracellular pH buffering molecule, Zn/Cu ion chelator, antioxidant and anti …

Transglutaminases (TGs; EC 2.3. 2.13) are a family of structurally and functionally related
enzymes that catalyze Ca2-dependent post-translational modification of proteins by …

Tissue transglutaminase (TGase) has been implicated in both cell survival and apoptosis.
Here we investigate the role of TGase in β-amyloid-induced neurotoxicity using retinoic acid …

We report that a significant number of autistic children have serum levels of IgA antibodies
above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these …

Transglutaminases (TGases) are enzymes that catalyze covalent isopeptide crosslinks
between reactive lysine and glutamine residues in proteins. Higher than normal local …

Mammalian transglutaminases (TGs) catalyze the irreversible post-translational
modifications of proteins, the most prominent of which is the calcium-dependent formation of …