Antioxidants are known to minimize oxidative stress by interacting with free radicals
produced as a result of cell aerobic reactions. Oxidative stress has long been linked to many …

Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary,
lifestyle and environmental factors, which favors a chronic positive energy balance, leading …

The endogenous disulfide α-lipoic acid (LA) is an essential mitochondrial co-factor. In
addition, LA and its reduced counterpart dihydro lipoic acid form a potent redox couple with …

Cancer cells convert glucose preferentially to lactate even in the presence of oxygen
(aerobic glycolysis–Warburg effect). New concepts in cancer treatment aim at inhibition of …

Unlike normal cells, tumor cells survive in a specific redox environment where the elevated
reactive oxygen species contribute to enhance cell proliferation and to suppress apoptosis …

We discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits
proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability …

Abstract Background: Resistance to cisplatin (Cisp) in the treatment of breast cancer is a
major obstacle. Alpha-lipoic acid (ALA) has both antioxidant and oxidant properties. ALA …

Alpha-lipoic acid (ALA, thioctic acid), a naturally-occurring essential dithiol compound, has
become a common ingredient in many pharmaceutical and food supplement products (FSP) …

Introduction: Alpha lipoic acid (ALA) is an essential mitochondrial co-factor and, as a free
molecule, it can exert multi-level immunomodulatory functions. Both ALA and its reduced …

Α-lipoic acid, a nutrient with both, antioxidant and oxidant activity induces apoptosis in a
variety of cells. Owing to its proapoptotic potency Α-lipoic acid has been suggested for the …