Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Since the discovery in the 1980s that nitric oxide (NO) is in fact the elusive endothelium-
derived relaxing factor, it has become evident that NO is not only a major cardiovascular …

The potential beneficial effects of the antioxidant properties of vitamin C have been
investigated in a number of pathological conditions. In this review, we assess both clinical …

Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the
pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought to …

Insulin stimulates production of NO in vascular endothelium via activation of
phosphatidylinositol (PI) 3-kinase, Akt, and endothelial NO synthase. We hypothesized that …

Drugs currently approved to coat stents used in percutaneous coronary interventions do not
discriminate between proliferating vascular smooth muscle cells (VSMCs) and endothelial …

We recently reported a mouse model of chronic electronic cigarette (e-cig) exposure-
induced cardiovascular pathology, where long-term exposure to e-cig vape (ECV) induces …

Background The expression of calcium/calmodulin‐dependent kinase IV (CaMKIV) was
hitherto thought to be confined to the nervous system. However, a recent genome‐wide …

In the aorta of spontaneously hypertensive rats (SHR), the endothelial dysfunction is due to
the release of endothelium‐derived contracting factors (EDCFs) that counteract the …