Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

S Mishra, SS Verma, V Rai, N Awasthee… - Cellular and Molecular …, 2019 - Springer
The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases.
Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small …

Long non‐coding RNA s as an epigenetic regulator in human cancers

Y Kondo, K Shinjo, K Katsushima - Cancer science, 2017 - Wiley Online Library
Recent studies have described the important multiple roles of long non‐coding RNA s (lnc
RNA s) during oncogenic transformation. Because the coding genome accounts for a small …

Long noncoding RNA and cancer: a new paradigm

A Bhan, M Soleimani, SS Mandal - Cancer research, 2017 - AACR
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner

L Mei, C Shen, R Miao, JZ Wang, MD Cao… - Cell death & …, 2020 - nature.com
The RNA methyltransferase NSUN2 has been involved in the cell proliferation and
senescence, and is upregulated in various types of cancers. However, the role and potential …

LncRNA TUG1 sponges miR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification

C Yu, L Li, F Xie, S Guo, F Liu, N Dong… - Cardiovascular …, 2018 - academic.oup.com
Aims Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a vital role in
cardiovascular physiology and pathology. Although the lncRNA TUG1 is implicated in …

5-methylcytosine RNA methyltransferases and their potential roles in cancer

M Li, Z Tao, Y Zhao, L Li, J Zheng, Z Li… - Journal of Translational …, 2022 - Springer
Abstract In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key
player in regulating RNA metabolism and function through coding as well as non-coding …

LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: a novel approach to personalized medicine

S Fattahi, M Kosari‐Monfared… - Journal of cellular …, 2020 - Wiley Online Library
Gastric cancer is the third leading cause of cancer death with 5‐year survival rate of about
30–35%. Since early detection is associated with decreased mortality, identification of novel …

LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years

C Tam, JH Wong, SKW Tsui, T Zuo, TF Chan… - Applied microbiology and …, 2019 - Springer
Long noncoding RNA (lncRNA) is a kind of RNAi molecule composed of hundreds to
thousands of nucleotides. There are several major types of functional lncRNAs which …

Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

G Khalili-Tanha, M Moghbeli - Cellular & Molecular Biology Letters, 2021 - Springer
Resistance against conventional chemotherapeutic agents is one of the main reasons for
tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are …