One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Great progress has been made in understanding the regulation of expression of genes
involved in secondary metabolism. Less is known about the mechanisms that govern the …

The beta-lactam antibiotics have been serving mankind for over 70years. Despite this old
age, they continue to provide health to the world population by virtue of industrial production …

The genus Emericellopsis is found in terrestrial, but mainly in marine, environments with a
worldwide distribution. Although Emericellopsis has been recognized as an important …

Several species of the filamentous fungus Fusarium colonize plants and produce toxic small
molecules that contaminate agricultural products, rendering them unsuitable for …

Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …

Cephalosporins comprise a β-lactam antibiotic class whose first members were discovered
in 1945 from the fungus Cephalosporium acremonium. Their clinical use for Gram-negative …

Cephalosporins are currently the most widely used antibiotics in clinical practice. The main
strain used for the industrial production cephalosporin C (CPC) is Acremonium …

Penicillins and cephalosporins are β‐lactam antibiotics widely used in human medicine. The
biosynthesis of these compounds starts by the condensation of the amino acids l‐α …

Secondary metabolites possess a lot of biological activities, and to achieve their functions,
transmembrane transportation is crucial. Elucidation of their transport mechanisms in the cell …