Allogeneic CAR T cells: an alternative to overcome challenges of CAR T cell therapy in glioblastoma
D Martínez Bedoya, V Dutoit, D Migliorini - Frontiers in immunology, 2021 - frontiersin.org
Chimeric antigen receptor (CAR) T cell therapy has emerged as one of the major
breakthroughs in cancer immunotherapy in the last decade. Outstanding results in …
breakthroughs in cancer immunotherapy in the last decade. Outstanding results in …
Progress in building clinically relevant patient‐derived tumor xenograft models for cancer research
W Wang, Y Li, K Lin, X Wang, Y Tu… - Animal Models and …, 2023 - Wiley Online Library
Patient‐derived tumor xenograft (PDX) models, a method involving the surgical extraction of
tumor tissues from cancer patients and subsequent transplantation into immunodeficient …
tumor tissues from cancer patients and subsequent transplantation into immunodeficient …
Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies
JC Bayley, CC Hadley, AO Harmanci, AS Harmanci… - Science …, 2022 - science.org
One-fifth of meningiomas classified as benign by World Health Organization (WHO)
histopathological grading will behave malignantly. To better diagnose these tumors, several …
histopathological grading will behave malignantly. To better diagnose these tumors, several …
A Transcriptome-Based Precision Oncology Platform for Patient–Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies
PS Mundi, FS Dela Cruz, A Grunn, D Diolaiti… - Cancer discovery, 2023 - AACR
Predicting in vivo response to antineoplastics remains an elusive challenge. We performed
a first-of-kind evaluation of two transcriptome-based precision cancer medicine …
a first-of-kind evaluation of two transcriptome-based precision cancer medicine …
Newly established patient-derived organoid model of intracranial meningioma
S Yamazaki, F Ohka, M Hirano, Y Shiraki… - Neuro …, 2021 - academic.oup.com
Background Recent comprehensive studies have revealed several molecular alterations
that are frequently found in meningiomas. However, effective treatment reagents targeting …
that are frequently found in meningiomas. However, effective treatment reagents targeting …
The role of pharmacotherapy in treatment of meningioma: a systematic review
Simple Summary For the last 35 years, various systemic therapies for recurrent or refractory
meningiomas have been investigated. The present review aggregated the currently …
meningiomas have been investigated. The present review aggregated the currently …
Experimental murine models for colorectal cancer research
Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it
metastasizes, it has dramatic consequences. Murine models in CRC research are important …
metastasizes, it has dramatic consequences. Murine models in CRC research are important …
Targeting histone deacetylase 6 (HDAC6) to enhance radiation therapy in meningiomas in a 2D and 3D in vitro study
J Na, S Shaji, CO Hanemann - EBioMedicine, 2024 - thelancet.com
Background External radiation therapy (RT) is often a primary treatment for inoperable
meningiomas in the absence of established chemotherapy. Histone deacetylase 6 (HDAC6) …
meningiomas in the absence of established chemotherapy. Histone deacetylase 6 (HDAC6) …
Advances in the systemic therapy for recurrent meningiomas and the challenges ahead
Y Li, J Drappatz - Expert Review of Neurotherapeutics, 2023 - Taylor & Francis
Introduction Meningiomas represent the most common primary neoplasms of the central
nervous system (CNS). 20% present with atypical (WHO grade II) or malignant (grade III) …
nervous system (CNS). 20% present with atypical (WHO grade II) or malignant (grade III) …
Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations
AN Habowski, DP Budagavi, SD Scherer, AB Aurora… - Cancers, 2024 - mdpi.com
Simple Summary Over the last two decades, there has been a major shift in cancer research
models. What was once dominated by genetically engineered mice models and fast-growing …
models. What was once dominated by genetically engineered mice models and fast-growing …