Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions

P Jayachandran, F Battaglin, C Strelez, A Lenz… - Oncogene, 2023 - nature.com
Exploring the relationship between various neurotransmitters and breast cancer cell growth
has revealed their likely centrality to improving breast cancer treatment. Neurotransmitters …

Recent Advancement in Breast Cancer Research: Insights from Model Organisms—Mouse Models to Zebrafish

SS Singhal, R Garg, A Mohanty, P Garg, SK Ramisetty… - Cancers, 2023 - mdpi.com
Simple Summary The current article provides an overview of the significance of using
various mouse and zebrafish models in cancer research. In addition, this review discusses …

Sleep disruption and cancer: chicken or the egg?

A Berisha, K Shutkind, JC Borniger - Frontiers in neuroscience, 2022 - frontiersin.org
Sleep is a nearly ubiquitous phenomenon across the phylogenetic tree, highlighting its
essential role in ensuring fitness across evolutionary time. Consequently, chronic disruption …

Understanding and modeling nerve–cancer interactions

TT Le, MJ Oudin - Disease Models & Mechanisms, 2023 - journals.biologists.com
The peripheral nervous system plays an important role in cancer progression. Studies in
multiple cancer types have shown that higher intratumoral nerve density is associated with …

From pain to tumor immunity: influence of peripheral sensory neurons in cancer

U Mardelle, N Bretaud, C Daher, V Feuillet - Frontiers in Immunology, 2024 - frontiersin.org
The nervous and immune systems are the primary sensory interfaces of the body, allowing it
to recognize, process, and respond to various stimuli from both the external and internal …

Regulating tumor innervation by nanodrugs potentiates cancer immunochemotherapy and relieve chemotherapy-induced neuropathic pain

S Zuo, Z Wang, X Jiang, Y Zhao, P Wen, J Wang, J Li… - Biomaterials, 2024 - Elsevier
Sympathetic nerves play a pivotal role in promoting tumor growth through crosstalk with
tumor and stromal cells. Chemotherapy exacerbates the infiltration of sympathetic nerves …

Bisphosphonate-Based Hydrogel with pH-Responsive Minocycline Release Inhibits Microglia/Macrophages of M1 Polarization for Spinal Cord Injury Therapy

Y Li, Z Wang, S Pei, R Chen, Y Li, Y Liang… - ACS Materials …, 2024 - ACS Publications
After spinal cord injury (SCI), the persistent presence of pro-inflammatory microglia/
macrophages (M1 phenotype) in injury lesion is one of the major reasons for inducing …

Retrograde tracing of breast cancer‐associated sensory neurons

S Kallogjerovic, I Velázquez‐Quesada… - Journal of …, 2024 - Wiley Online Library
Breast cancer is one of the leading causes of mortality among women. The tumour
microenvironment, consisting of host cells and extracellular matrix, has been increasingly …

A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation

SL Galappaththi, B Katz, PH Howze IV, G Hoover… - Cancers, 2023 - mdpi.com
Simple Summary High-throughput methods that accurately monitor cancer-induced
neuronal differentiation are a prerequisite to developing genetic and drug screening …

Tools and Model Systems to Study Nerve-Cancer Interactions

PL Wang, NA Lester, JA Guo, J Su, C Shiau… - Cancer …, 2023 - Springer
Since the initial observations of nerve involvement in tumors dating back to the late
nineteenth century, considerable knowledge has accumulated around the biology of nerve …