The incidence of esophageal adenocarcinoma (EAC) has increased in many Western
countries and is higher in men than women. Some risk factors for EAC have been identified …

Evidence indicates that diet, nutrition, lifestyle, the environment, the microbiome, and other
exogenous factors have pathogenic roles and also influence the genome, epigenome …

Immunotherapy strategies targeting immune checkpoints such as the CTLA4 and CD274
(programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell …

Abstract Purpose of Review In this review, we describe molecular pathological epidemiology
(MPE) studies from around the world that have studied diet and/or lifestyle factors in relation …

Molecular pathological epidemiology (MPE) is an integrative transdisciplinary field that
addresses heterogeneous effects of exogenous and endogenous factors (collectively …

As one of causal inference methodologies, the inverse probability weighting (IPW) method
has been utilized to address confounding and account for missing data when subjects with …

The recently rapid increase of obesity and type 2 diabetes mellitus has caused great burden
to our society. A positive association between type 2 diabetes and risk of colorectal cancer …

Background Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has
been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the …

Precision medicine has a goal of customizing disease prevention and treatment strategies.
Under the precision medicine paradigm, each patient has unique pathologic processes …

Introduction: Inflammation is an established process in colorectal cancer development and a
hallmark of progression, and pro-inflammatory cytokines have been implicated in the …