Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …

The incidence and mortality of cancer are the major health issue worldwide. Apart from the
treatments developed to date, the unsatisfactory therapeutic effects of cancers have not …

Children with Down syndrome are at an elevated risk of leukemia, especially myeloid
leukemia (ML-DS). This malignancy is frequently preceded by transient abnormal …

Down syndrome is associated with genome-wide perturbation of gene expression, which
may be mediated by epigenetic changes. We perform an epigenome-wide association study …

Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal
evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy …

Structural and numerical alterations of chromosome 21 are extremely common in
hematological malignancies. While the functional impact of chimeric transcripts from fused …

Patients with GATA2 deficiencyharbor de novo or inherited germline mutations in the GATA2
transcription factor gene, predisposing them to myeloid malignancies. There is considerable …

Abstract Constitutional trisomy 21 (T21) is a state of aneuploidy associated with high
incidence of childhood acute myeloid leukemia (AML). T21-associated AML is preceded by …

INTRODUCTION Leukemia is the most common cancer in children, with the first genetic
alterations often occurring during fetal development. These initiating events generate …