[HTML][HTML] Genetic compensation: A phenomenon in search of mechanisms
MA El-Brolosy, DYR Stainier - PLoS genetics, 2017 - journals.plos.org
Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …
TET enzymes, TDG and the dynamics of DNA demethylation
DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …
Although enzymes that catalyse DNA methylation have been well characterized, those that …
[HTML][HTML] Reversing DNA methylation: mechanisms, genomics, and biological functions
Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …
and is dynamically regulated during development. Compelling evidence now suggests that …
[HTML][HTML] Common stemness regulators of embryonic and cancer stem cells
C Hadjimichael, K Chanoumidou… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
[HTML][HTML] TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Tet family proteins and 5-hydroxymethylcytosine in development and disease
L Tan, YG Shi - Development, 2012 - journals.biologists.com
Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …
5mC) has emerged as an important epigenetic modification that plays essential roles in …
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection
HK Long, NP Blackledge… - Biochemical Society …, 2013 - portlandpress.com
Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine
base in the context of CpG dinucleotides. This modification creates a binding site for MBD …
base in the context of CpG dinucleotides. This modification creates a binding site for MBD …
[HTML][HTML] Epigenetic mechanisms of epidermal differentiation
C Moltrasio, M Romagnuolo, AV Marzano - International journal of …, 2022 - mdpi.com
Keratinocyte differentiation is an essential process for epidermal stratification and stratum
corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start …
corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start …
[HTML][HTML] Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors
Cell type-specific master transcription factors (TFs) play vital roles in defining cell identity
and function. However, the roles ubiquitous factors play in the specification of cell identity …
and function. However, the roles ubiquitous factors play in the specification of cell identity …
[HTML][HTML] Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells
Abstract Background Ten-Eleven Translocation (TETs) proteins mediate the oxidation of 5-
methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 is expressed at high levels …
methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 is expressed at high levels …