Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury
in the adult constitutes an excellent paradigm to investigate the mechanisms whereby …

Histone lysine‐specific demethylase 1 (LSD1) is the first discovered and reported histone
demethylase by Dr. Shi Yang's group in 2004. It is classified as a member of amine oxidase …

Transcription factors and chromatin modifiers are important in the programming and
reprogramming of cellular states during development,. Transcription factors bind to …

DNA and histone chromatin modifying enzymes play a crucial role in chromatin remodeling
in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified …

Natural products generally fall into the biologically relevant chemical space and always
possess novel biological activities, thus making them a rich source of lead compounds for …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …

Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …

In response to muscle injury, muscle stem cells integrate environmental cues in the
damaged tissue to mediate regeneration. These environmental cues are tightly regulated to …

Skeletal muscle development and regeneration is governed by the combined action of Myf5,
MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These …

Mitochondria are crucial organelles that control cellular metabolism through an integrated
mechanism of energy generation via oxidative phosphorylation. Apart from this canonical …